HUMAN GENETICS UNIT

Faculty of Medicine, University of Colombo, Sri Lanka Established in 1983
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PUBLICATIONS

2013
 
Sumathipala DS, Abeysekara AAGS, Jayasekara RW, Tallaksen CME, Dissanayake VHW. Autosomal dominant hereditary ataxia in Sri Lanka. BMC Neurology 2013, 13:39. doi:10.1186/1471-2377-13-39.
 
Andraweera PH, Dekker GA, Dissanayake VHW, Bianco-Miotto T, Jayasekara RW, Roberts CT. Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri Lanka. The Journal of Maternal-Fetal and Neonatal Medicine 2013;26(5):532-6. doi: 10.3109/14767058.2012.743520. Epub 2012 Nov 21.
 

2012
 
Wettasinghe TK, Jayasekara RW, Dissanayake VHW. The low frequency of Y chromosome microdeletions in subfertile males in the Sinhalese population of Sri Lanka. Indian Journal of Human Genetics 2012;18(3):320-325.
 
Padeniya PM, Godapitiya I, Pathirana Dr, Jayasekara RW, Dissanayake VHW. A Sri Lankan Child with 48,XXXX syndrome. Indian Journal of Paediatrics. doi: 10.1007/s12098-013-0995-x
 
Samarakoon L, Sirisena ND, Wettasinghe KT, Kariyawasam KWJC, Jayasekara RW, Dissanayake VHW. Prevalence of chromosomal abnormalities in Sri Lankan women with primary amenorrhea. Journal of Obstetrics and Gynaecology Research 2013;39(5):991–997. doi: 10.1111/j.1447-0756.2012.02063.x. Epub 2012 Dec.
 
Sumathipala DS, Wijesiriwardena B, Gamage TH, Jayasekara RW, Dissanayake VHW. An Infant Born to a Mother with Gestational Diabetes Presenting with 49,XXXXY Syndrome and Renal Agenesis-A Case Report. Journal of Clinical Research and Paediatric Endocrinology. 2012 December; 4(4): 223–225.
 
Wetthasinghe TK, Sirisena ND, Adraweera1 PH, Jayasekara RW, Dissanayake VHW. A Case Series of Five Sri Lankan Patients with Ovotesticular Disorder of Sex Development. Clinical Pediatric Endocrinology, 2012;21(4):69-73.
 
Katulanda P, Rajapakse JRDK, Kariyawasamv KDJC, Jayasekara RW, Dissanayake VHW. An adolescent with 48,XXYY syndrome with hypergonadotrophic hypogonadism, attention deficit hyperactive disorder and renal malformations. Indian Journal of Endocrinology and Metabolism. 2012 Sep;16(5):824-6. doi: 10.4103/2230-8210.100642.
 
Gamage TH, Godapitiya IUH, Nanayakkara S, Jayasekara RW, Dissanayake VHW. A child with mosaicism for deletion (14)(q11.2q13). Indian Journal of Human Genetics 2012, 18(1): 130-33.
 
Dissanayake VHW, Sirisena ND, Weerasekera LY, Gammulla CG, Seneviratne HR, Jayasekara RW. A Candidate Gene Study of Genetic Thrombophilic Polymorphisms in Pre-eclampsia and Recurrent Pregnancy Loss in Sinhalese women. Journal of Obstetric and Gynaecology Research 2012 Apr 30. doi: 10.1111/j.1447-0756.2012.01846.x.
 
Dissanayake VHW, Gunawardena ND, Gunasekara NCA, Siriwardhana DRS, Senarath N. Shift in the transmission pattern of dengue serotypes and concurrent infection with more than one dengue virus serotype. Ceylon Medical Journal 2011; 56: 176-178.
 
Harendra GG, Jayasekara RW, Dissanayake VHW. Haplotypes of heparin-binding epidermal-growth-factor-like growth factor gene are associated with pre-eclampsia.Journal of Obstetric and Gynaecology Research 2012 Jan;38(1):239-46.
 

2011
 
Dissanayake VHW, Jayasinghe JD, Tilakaratna V, Jayasekara RW. A novel mutation in SLC37A4 gene in a Sri Lankan boy with glycogen storage disease type Ib associated with very early onset neutropenia. Journal of Molecular Genetics and Medicine, 2011;5:262-263 .
 
Dissanayake VHW, Samarakoon PS, Scaria V, Patowary A, Sivasubbu S, Gokhale R. The Sri Lankan Personal Genome Project: an overview. Sri Lanka Journal of Biomedical Informatics 2011; 2:4-9.
 
Samarakoon PS, Jayasekara RW, Dissanayake VHW. The Sri Lankan Genome Variation Database. Sri Lanka Journal of Biomedical Informatics 2011;2(1):10-21.
 
Harendra GG, Jayasekara RW, Dissanayake VHW. In silico analysis of Single Nucleotide Polymorphisms (SNPs) in the Heparin-Binding EGF-like Growth Factor (HBEGF) gene and their allelic profiles in the Sri Lankan population: a comprehensive approach to prioritise SNPs for candidate gene studies. Sri Lanka Journal of Bio-Medical Informatics 2011;2(1):22-38.
 

2010
 
Wettasinghe TK, Jayasekara RW, Dissanayake VHW. Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhalese population in Sri Lanka. Human Reproduction 2010;25(12):3152-6.
 
Dissanayake VHW, Bandarage P, Pedurupillay CRJ, Jayasekara RW. A Sri Lankan child with 49,XXXXY syndrome. Indian Journal of Human Genetics 2010;16(3):164-165.
 
Samaranayake TN, Fernando SD, Dissanayake VHW. A candidate gene study of susceptibility to cutaneous leishmaniasis in Sri Lanka. Tropical Medicine and International Health, 2010;15(5):632-8.
 

2009
 
Dissanayake VHW, Gammulla CG, Jayaweera LSD, Jayasekara RW. Prevalence of genetic thrombophilic polymorphisms in the Sri Lankan population - implications for association study design and clinical genetic testing services. Experimental and Molecular Pathology 2009;87(2): 159�162.
 
Dissanayake VHW, Athapaththu AMMH, Opanayake DJS, Hidellage NT, Wijetunge K,  Pedurupillay CRJ. Chromosomal abnormalities in patients with recurrent spontaneous pregnancy loss and sub-fertility. Sri Lanka Journal of Obstetrics and Gynaecology 2009;31(2):84-87.
 
Dissanayake VHW, Jayasekara RW, Seneviratne HR, Kalsheker N, Broughton Pipkin F, Morgan L. A study of three candidate genes for pre-eclampsia in a Sinhalese population from Sri Lanka. Journal of Obstetrics and Gynaecology Research 2009;35(2):234-242.

 

Simpson R, Dissanayake V, Douglas-Jones R, Sariola S. Biomedical Research in South Asia - Ethical Review, Remit and Responsibilities. The News Letter of the International Institute for Asian Studies, No. 52 Winter 2009:27.

 

Dissanayake VHW. Genetics of Pre-eclampsia and the weight of babies at birth - Clinical and Genetic Studies in Sri Lanka. Ceylon Medical Journal 2009;54(3):90-9

2008

Samaranayake TN, Dissanayake VHW, Fernando SD. Clinical manifestations of cutaneous leishmaniasis in Sri Lanka � possible evidence for a genetic susceptibility among Sinhalese.
Annals of Tropical Medicine and Parasitology 2008;102(5):383-90.


Dissanayake VHW, Jayasekara RW. Cytogenetic testing in paediatrics: Some aspects of the Sri Lankan scenario.
Sri Lanka Journal of Paediatrics 2008;37(2):38-41. 
 
Dissanayake VHW. Integrating advances in genetics into day to day clinical practice: a wake up call for health care professionals. Journal of the Ruhunu Clinical Society, in Press.
 
2007
 
Dissanayake VHW, Tower C, Broderick A, Stocker LJ, Seneviratne HR, Jayasekara RW, Kalsheker N, Broughton Pipkin F, Morgan L.
Polymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeans.
Molecular Human Reproduction 2007; 13(6):425-9. Epub 2007 Mar 28.

Dissanayake VHW, Samarasinghe HD, Jayasekara RW, Seneviratn HR, Morgan L, Broughton Pipkin F.
Morbidity and mortality associated with pre-ecalmpsia among Sinhalese women delivering in two tertiary care hospitals in Sri Lanka.
Obstetrics and Gynaecology Research 2007; 33 (1): 56�62.

BEFORE 2007 (Classifed into subjects)
 
Clinical Genetics

Senanayake H, de Silva MV, Fernando MS, Jayasekara R.
Female karyotype (XX) in patients with ambiguous genitalia does not guarantee the absence of intra-abdominal testes.
Ceylon Medical Journal 2000;45(2):69-70
 
De Silva AP, Seneviratne SL, Gunatilake SB, Fonseka M, Jayasekara R, De Silva HJ.
A family with alkaptonuria showing quasidominant inheritance.
 
Jayasekara R, Jiffry MTM.
Oral abnormalities in 45XO Turner Syndrome in Sri Lanka.
Sri Lanka Dental Journal 1990;19:36-39
 
Jayasekara R.
Chromosome anomalies in Sri Lanka - A cytogenetic profile.
Ceylon Journal of Medical Sciences 1988;31(1):1-5

Ethics
 
Dissanayake VHW, Lanerolle RD, Mendis N.
Research ethics and ethical review committees in Sri Lanka: a 25 year journey.
Ceylon Medical Journal 2006;51(3): 110-113.
 
Simpson B, Dissanayake VHW, Jayasekara RW.
Contemplating choice: attitudes towards intervening in human reproduction in Sri Lanka.
New Genetics and Society 2005;24(1):99-117.

Simpson B, Dissanayake VHW, Wickramasinghe D, Jayasekara RW.
Prenatal testing and pregnancy termination in Sri Lanka: views of medical students and doctors.
Ceylon Medical Journal 2003;48(4):129-132.

Dissanayake VHW, Simpson R, Jayasekara RW.
Attitudes towards the new genetic and assisted reproductive technologies in Sri Lanka: a preliminary report.
Jayasekara R, Kristl GB, Wertelecki W.
Acceptance of Genetic services: a study of physicians in Colombo, Sri Lanka.
Journal of Biosocial Sciences 1988;20:1-7
 
Jayasekara R.
The attitude of doctors and students towards a Genetic service in an Asian country: Sri Lanka.
Asia Oceania Journal of Obstetrics & Gynaecology 1989;15(3):267-270
 
Jayasekara R.
Acceptance of a Genetic service in Sri Lanka: a student view point.
Ceylon Journal of Medical Sciences 1986;29(2):67-73

Genetic Testing

Welihinda J, Karunanayake E, Jayasekara R, Peiris JB, Ulf Pettersson, Claes Wadelius.
Deletion screening of Sri Lankan Duchenne Muscular Dystrophy patients using the Polymerase Chain Reaction.
Annals of Tropical Paediatrics 1993;13:83-86
 
De Mel T, Jayasekara R, Warnasuriya N.
Screening for Turner Syndrome, How useful is the Buccal Smear test ?
Ceylon Medical Journal 1992;37:83-84

Human Growth and Development

Jayasekara R, Lasswell-Hoff J, Garner C, Kristl G, Hoff C.
Adolescent growth in stature among Sinhalese males: preliminary results of a cross-sectional study.
Human Biology 1988;60(6):825-831

Jayasekara R.
Factors Affecting The Age At Natural Menopause In Sinhalese Women.
Ceylon Journal of Medical Sciences 1994;37:23-27

Jayasekara R, Goonawardene S.
The influence of socio-economic factors on mean age of menarchae In Sri Lanka.
Ceylon Medical Journal 1987;32:89-94

Jayasekara R, Street J.
Parental age and parity in Dyslexic boys.
Journal of Biosocial Sciences 1978;10:255-261

Informatics

Dissanayake VHW, Jayasekara R
Pattern of use of medical information made available via an Internet website.
Ceylon Medical Journal 1999; 44 (2):14-17 [ full text pdf ]

Dissanayake VHW
Sri Lankan medical bibliographic resources.
Ceylon Medical Journal 1997; 42(4):200
 
Pre-eclampsia
 
Dissanayake VHW, Morgan L, Broughton Pipkin F, Vathanan V, Premaratne S, Jayasekara RW, Seneviratne HR.
The urine protein heat coagulation test � a useful screening test for proteinuria in pregnancy in developing countries: A method validation study.
 
Population Genetics

Papiha SS, Mastana SS, Jayasekara R.
Genetic variations in Sri Lanka.
Human Biology 1996;68(5):707-737

Papiha SS, Mastana SS, Purandre CA, Jayasekara R, Charkarborty R.
Population genetic study of three VNTR loci (D2S44, D7S22 and D12S11) in five ethnically defined populations of the Indian Subcontinent.
Human Biology 1996;68(5):819-835

Jayasekara R, Mastana SS, Papiha SS.
Distribution of Group specific Component (GC) and Transferrin (TF) subtypes in populations of Sri Lanka.
Gene Geography 1994;8:151-156
 
Mastana SS, Jayasekara R, Fisher P, Sokol RJ, Papiha SS.
Genetic polymorphism of Orosomucoid (ORM) in populations of the United Kingdom, Indian Subcontinent and Cambodia.
Japanese Journal of Human Genetics 1993;38:289-296

Mastana SS, Jayasekara R, Papiha SS.
Genetic diversity in Sri Lanka: some implications in paternity and forensic testing.
Advances in Forensic Haemogenetics.1993;5:632-634

Twin Research

Sumathipala A, Fernando DJS, Siribaddana SH, Abeysingha MRN, Jayasekare RW, Dissanayake VHW, De Silva N. Establishing a twin register in Sri Lanka.